In 1812, three years before the summer in which Frankenstein was conceived, Percy Bysshe Shelley published the first of this couple's reinterpretations of the Prometheus myth, suggesting that the significance of the titan's carrying fire to earth was as a means of introducing flesh-eating to humanity. From that point on the pristine human civilization was ravaged by disease. This seventeenth of the sometimes very long endnotes to his "philosophical poem" Queen Mab (a note to VIII.211) was republished as a pamphlet called A Vindication of Natural Diet in 1813.