Life Without Soul was directed by Joseph W. Smiley, and stars Percy Darrell Standing as "the Brute Man" and William A. Cohill as Dr. William Frawley. After the Creature kills Frawley's sister, he pursues it across Europe; at the conclusion, Frawley shoots the Monster immediately before dying of exhaustion.
Life Without Soul was later remade as Il Mostro di Frankenstein (1920).