Early fifteenth-century Basel was a religious center, hosting a papal election and a reform council; later it was the home of Erasmus, who is buried in Basel's cathedral. In the sixteenth century, Basel was a center of Reformation theology; John Calvin took refuge in the city.
Basel's university was founded in 1460; Paracelsus was a famous early alumnus. Much later, in the nineteenth century, Friedrich Wilhelm Nietzsche taught at the the University of Basel.