Lloyd was first a student, and later a friend and lodger, of Coleridge; he was also a friend of Lamb, with whom he published a volume of verse and prose. Lamb refers to him in "The Old Familiar Faces" as "a friend." Always prone to epileptic fits, in 1811 Lloyd began to show signs of mental instability. He was placed under the care of Erasmus Darwin, where he wrote a novel, Edmund Oliver, which contains vindictive and only slightly disguised portraits of William Godwin, Mary Wollstonecraft, and Coleridge. He spent the last years of his life in an asylum near Versailles.